What files are open?                       lsof
What process has a particular file open?   lsof /path/to/the/file
What files in some directory are open?     lsof +D /path/to/the/dir
What files does some user have open?       lsof -u username
What files do a group of users have open?  lsof -u user1,user2
What files are open by process name?       lsof -c procname
What files are open by PID?                lsof -p 123
What files are open by other PIDs?         lsof -p ^123
Show network activity                      lsof -i
What files are open by port?               lsof -i :25
                                           lsof -i :smtp
List PIDs                                  lsof -t
Show network activity for a user           lsof -a -u username -i
Show socket use                            lsof -U
Show NFS activity                          lsof -N